As fantasy football managers prepare for Week 4, several key players have been identified as must-starts or sits based on their recent performances and matchups. Running back Omarion Hampton is recommended as a start despite facing Seattle’s tough defense, owing to his previous strong showings including a 17.5-point game in Week 2. Conversely, Bucky Irving is advised to sit due to declining weekly points and a challenging matchup against Green Bay, whose offense has struggled recently.

In the wide receiver category, DJ Moore emerges as a valuable start with Josh Allen throwing his way and promising production despite a recent injury-related dip. Meanwhile, Jaylen Waddle is a sit with an average of just 9.8 points per game this season, and his performances have not exceeded 12.5 points in recent years. His upcoming game against the Denver Broncos offers only a middling matchup as the 49ers rank 14th in fantasy points allowed to wide receivers.

For tight ends, Kenyon Sadiq is highlighted as a breakout star after scoring 23.5 fantasy points in Week 3 and benefiting from the New York Jets’ steadily productive offense. On the flip side, Juwan Johnson is recommended to sit against the Atlanta Falcons, who rank among the stingiest defenses against tight ends this year, and his current high touchdown-dependent scoring may not be sustainable.

Quarterback Brock Purdy stands out as a reliable start with at least 21 points scored each game so far, including two games reaching 28 points or more. Despite Denver’s relatively generous allowance to quarterbacks, his consistency makes him a strong choice. On the other hand, Jalen Hurts has struggled recently and faces a Los Angeles Rams defense that limits quarterback fantasy points, making him a sit candidate. Defensively, the Kansas City Chiefs are a solid start against Las Vegas, who have allowed the most points to opposing defenses, whereas the New Orleans Saints face a tough test against Atlanta’s high-scoring offense and should be avoided.