Colossal Biosciences has unveiled a new artificial intelligence platform called GenoMorph designed to accelerate efforts in de-extinction, specifically targeting species with limited genetic material available. The platform integrates advanced 3D morphology, comparative genomics, and developmental biology to pinpoint key genes for editing, even when only a few genomes exist. This capability is crucial for projects like the resurrection of the dodo bird, which has only one identified genome available, compared to the woolly mammoth project’s extensive genome database.

The development of GenoMorph drew on data from birds closely related to the dodo, including chickens, quail, ducks, and pigeons, as well as detailed 3D skull measurements from over 70 bird species. By learning which DNA regions influence physical traits during development, the AI predicts the genetic "switches" responsible for unique features like the dodo’s distinctive cranial shape. To date, Colossal has identified about 2,300 promising editing targets for the dodo’s facial structure, streamlining the search for meaningful genetic differences that define extinct species.

In parallel with GenoMorph, Colossal has advanced gene-editing techniques to test these predicted genetic changes efficiently. The company developed a lipid nanoparticle delivery system to introduce gene-editing tools directly into bird embryos, enabling faster observation of developmental effects without waiting for full breeding cycles. Additionally, progress with the Nicobar pigeon, the dodo’s closest living relative, includes establishing a colony of 36 birds and successfully creating essential reproductive cells, which are pivotal for incorporating dodo traits.

Supporting Colossal’s innovation, Peter Diamandis, founder of XPRIZE and an investor in the company, launched NeoGenesis Capital, a venture fund dedicated to backing startups that utilize Colossal’s programmable biology platform. This endorsement highlights growing confidence in Colossal’s technologies, which not only aim to bring extinct species back to life but also promise broader advancements in health, agriculture, and conservation through precise genetic engineering.