Week 6 of the 2026 NFL season delivered a brutal injury report for fantasy football managers, with Philadelphia Eagles quarterback Jalen Hurts placed on injured reserve due to blood clots, sidelining him at least until Week 10 and potentially the remainder of the season. Hurts will be on blood thinners for three months, ruling him out of all football activities. Rookie Tanner McKee stepped up in Hurts’ absence, showing some promise by maintaining decent production among the Eagles’ skill players, which could lead to pass-heavy game plans moving forward. Alongside Hurts, Washington Commanders running back Jacory Croskey-Merritt was also put on injured reserve with a groin injury, putting their backfield stability into question.

Several running backs faced injury concerns as well, including Cleveland’s Quinshon Judkins and Arizona’s Jeremiyah Love who both missed time due to ankle issues. Judkins was ruled out of Week 6, with Cleveland relying on backups Jaleel McLaughlin and Audric Estime. The uncertainty persists with Judkins’ status for Week 7, increasing the value of backup running back Dylan Sampson. Arizona’s Love aggravated a preexisting ankle injury and missed time, allowing Bam Knight to showcase his explosiveness as the preferred option in the Cardinals’ backfield. These injuries underscore the volatility running backs face in fantasy leagues as teams manage player health.

Wide receiver injuries struck hard this week, with the San Francisco 49ers’ Mike Evans leaving Monday Night Football early due to an Achilles aggravation, though he reportedly avoided a tear and should return soon. The Rams suffered a major blow when wideout Davante Adams incurred a hamstring injury expected to keep him out six to ten weeks, which could impact their passing attack for the rest of the fantasy season. The Washington Commanders also faced a severe loss when Terry McLaurin tore his patellar tendon in Week 6, ending his season and reshaping the receiving depth chart; tight end Chig Okonkwo and receiver Treylon Burks have emerged as waiver wire targets amid the injury chaos.

Tight end Tyler Warren of the Colts was ruled out for Week 6 after a groin injury, but may return in Week 7, highlighting the precarious nature of groin injuries. On the quarterback front, Lamar Jackson remains day-to-day with an ankle ailment and could return soon for the Ravens, while Tampa Bay’s Baker Mayfield is expected to practice after a dislocated thumb kept him out for three weeks. These injury updates signal a pivotal point in the fantasy football season as managers scramble to adjust lineups amid multiple high-profile absences, making waiver pickups and monitoring injury reports more critical than ever heading into Week 7.