The latest installment of the Resident Evil franchise, directed by Zach Cregger, is set to debut on digital streaming platforms this week, including Prime Video, Apple TV, and YouTube Movies & TV. The film, released in theaters on September 18, 2026, quickly made an impact by earning $60.1 million in its opening weekend across 3,684 North American theaters, marking the franchise’s highest domestic debut to date. Starring Austin Abrams as a courier caught in a deadly virus outbreak, alongside Paul Walter Hauser, Kali Reis, and Zach Cherry, the film blends horror with dark comedy to strong box office results.

Resident Evil’s global box office haul has edged close to $400 million, with domestic earnings exceeding $157 million. These figures position it as the top-grossing film in the franchise’s live-action lineup, surpassing previous entries like 2016’s Resident Evil: The Final Chapter, which grossed $314.1 million worldwide. The film’s production budget stood at $75 million before marketing and distribution costs. Even while still playing in nearly 2,000 North American theaters, the movie is on track to surpass other 2026 horror hits like Backrooms, which collected around $400 million globally.

The story follows Bryan, played by Austin Abrams, a medical courier whose last-minute delivery in a snowy Racoon City turns into a night of chaos after he encounters a woman infected with a mutative virus. Cregger co-wrote the screenplay alongside Shay Hatten, maintaining a connection to the franchise’s video game origins through a fresh narrative approach. Rated R, the film taps into suspense and horror elements while exploring a new storyline in the Resident Evil universe, contributing to its strong critical and commercial reception.

Starting November 3, viewers can purchase Resident Evil on premium video on demand for $24.99 or rent the film for $19.99 on major digital platforms. This transition to home entertainment follows a record-breaking theatrical run and reflects a growing trend of simultaneous digital releases for blockbuster genre films. The digital launch is expected to further extend the film’s revenue stream as fans and new audiences alike gain access outside the cinema experience.